Regulation of natural killer cell differentiation

Across TCGA patient cohorts, RNA activity of the Regulation of natural killer cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GBP1, LAP3, and CD38, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of natural killer cell differentiation activity versus GBP1 in BRCA (Pearson r = 0.51).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	GBP1 →	+0.780	+0.039	<.001	<.001	3	9
LSCC	LAP3 →	+0.593	+0.091	<.001	<.001	3	9
BRCA	CD38 →	+0.738	+0.042	<.001	<.001	3	9
UCEC	APOL3 →	+0.698	+0.065	<.001	.001	2	9
COAD	CASP1 →	+0.489	+0.040	<.001	<.001	3	8
UCEC	GBP2 →	+0.581	+0.068	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032823 vs GBP1 — BRCA

Explore this scatter interactively →