Regulation of natural killer cell differentiation

Across TCGA patient cohorts, RNA activity of the Regulation of natural killer cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IL1R1, TGFB3, and CLEC4D, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of natural killer cell differentiation activity versus IL1R1 in COAD (Pearson r = 0.18).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	IL1R1 →	+0.483	+0.516	.002	.001	3	4
CCRCC	TGFB3 →	+0.436	+0.286	.006	.005	3	4
HNSC	CLEC4D →	+0.673	+0.463	<.001	.004	3	4
HNSC	CSF3R →	+0.831	+0.432	<.001	.004	3	4
HNSC	TMEM71 →	+0.547	+0.442	<.001	.003	3	4
LSCC	FPR2 →	+0.753	+0.658	.003	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032823 vs IL1R1 — COAD

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