Regulation of natural killer cell differentiation

Across TCGA cell cohorts, RNA activity of the Regulation of natural killer cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BAX, PHLDA3, and HEXB, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, BAX grouped by Regulation of natural killer cell differentiation-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	BAX →	-1.132	-1.128	.002	.001	3	5
SKIN	PHLDA3 →	-1.674	-1.048	<.001	<.001	3	5
SOFT_TISSUE	HEXB →	-1.567	-1.341	.007	.003	3	5
LUNG_NSCLC_LUSC	SEPSECS →	+0.863	+1.617	.001	.001	3	5
BONE	TAF13 →	-1.574	-1.630	.004	.001	3	4
LUNG_NSCLC_LUAD	ST3GAL2 →	+1.306	+0.795	.001	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BAX by Regulation of natural killer cell differentiation activity — OVARY

Explore this box plot interactively →