Regulation of natural killer cell differentiation

Across TCGA cell cohorts, RNA activity of the Regulation of natural killer cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GAS6, AXL, and ACTN1, each associated with the pathway in up to 17 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of natural killer cell differentiation activity versus GAS6 in LUNG_NSCLC_LUSC (Pearson r = 0.81).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	GAS6 →	+4.595	+0.464	<.001	<.001	3	17
LIVER	AXL →	+6.075	+1.148	<.001	.001	3	13
BONE	ACTN1 →	+1.750	+0.239	<.001	<.001	3	12
LIVER	FOSL1 →	+4.988	+1.017	<.001	.003	3	12
LUNG_NSCLC_LUSC	EMP3 →	+4.324	+0.340	<.001	.005	3	12
SOFT_TISSUE	PDCD1LG2 →	+2.044	+0.292	<.001	.002	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032823 vs GAS6 — LUNG_NSCLC_LUSC

Explore this scatter interactively →