Regulation of natural killer cell proliferation

Across TCGA patient cohorts, RNA activity of the Regulation of natural killer cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ICOS, HLA-F, and FCGR1B, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of natural killer cell proliferation activity versus ICOS in HNSC (Pearson r = 0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ICOS →	+0.949	+0.867	<.001	<.001	3	6
HNSC	HLA-F →	+1.070	+0.721	<.001	<.001	3	5
HNSC	FCGR1B →	+0.450	+0.822	<.001	<.001	3	5
UCEC	LINC01684 →	+0.419	+0.375	.005	.007	3	5
HNSC	ITK →	+0.824	+0.752	<.001	<.001	3	5
HNSC	ARHGAP9 →	+0.753	+0.554	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032817 vs ICOS — HNSC

Explore this scatter interactively →