Regulation of natural killer cell proliferation

Across TCGA cell cohorts, RNA activity of the Regulation of natural killer cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C6orf120, PPP1R3D, and NIBAN2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, C6orf120 grouped by Regulation of natural killer cell proliferation-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	C6orf120 →	-0.637	-1.260	.001	.009	3	4
LARGE_INTESTINE	PPP1R3D →	-0.691	-1.028	<.001	<.001	3	4
STOMACH	NIBAN2 →	-1.610	-1.633	.001	<.001	3	4
LIVER	WIPI1 →	-1.182	-1.589	.007	.006	3	4
BLOOD_Myeloma	ZMAT1 →	-2.435	-1.332	.001	<.001	3	4
STOMACH	OPTN →	-1.525	-1.331	.008	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

C6orf120 by Regulation of natural killer cell proliferation activity — BONE

Explore this box plot interactively →