Positive regulation of natural killer cell activation

Across TCGA patient cohorts, RNA activity of the Positive regulation of natural killer cell activation pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are WIPF1, BTK, and AIF1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of natural killer cell activation activity versus WIPF1 in OV (Pearson r = 0.07).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	WIPF1 →	+0.495	+0.055	.001	<.001	3	10
LSCC	BTK →	+0.518	+0.080	<.001	<.001	3	10
GBM	AIF1 →	+0.595	+0.057	<.001	<.001	3	9
GBM	HCLS1 →	+0.584	+0.057	<.001	<.001	3	9
OV	LCP1 →	+0.699	+0.070	<.001	<.001	3	9
OV	FERMT3 →	+0.472	+0.052	.006	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032816 vs WIPF1 — OV

Explore this scatter interactively →