Positive regulation of natural killer cell activation

Across TCGA patient cohorts, RNA activity of the Positive regulation of natural killer cell activation pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAM78A, FCER1G, and CTLA4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of natural killer cell activation activity versus FAM78A in HNSC (Pearson r = 0.12).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	FAM78A →	+0.803	+0.249	<.001	.009	3	5
HNSC	FCER1G →	+0.981	+0.348	<.001	.002	3	5
HNSC	CTLA4 →	+0.902	+0.246	<.001	.007	2	6
HNSC	INSYN2B →	+0.702	+0.373	<.001	.001	3	5
CCRCC	CMKLR1 →	+0.396	+0.156	.002	.005	3	5
CCRCC	SIGLEC1 →	+0.434	+0.180	.007	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032816 vs FAM78A — HNSC

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