Positive regulation of natural killer cell activation

Across TCGA cell cohorts, RNA activity of the Positive regulation of natural killer cell activation pathway is significantly associated with the shRNA dependency of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADAMTS4, ACLY, and MAP4K4, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ADAMTS4 grouped by Positive regulation of natural killer cell activation-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	ADAMTS4 →	-0.241	-0.455	<.001	<.001	3	7
BREAST	ACLY →	-0.570	-0.233	<.001	<.001	3	6
LUNG_NSCLC_LUAD	MAP4K4 →	-0.225	-0.190	.002	.002	3	6
URINARY_TRACT	GPR155 →	-0.360	-0.342	<.001	<.001	3	5
LIVER	TEAD4 →	+0.199	+0.241	.001	.007	3	5
BLOOD_Myeloma	LMBR1L →	-0.420	-0.188	.004	.007	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ADAMTS4 by Positive regulation of natural killer cell activation activity — STOMACH

Explore this box plot interactively →