Positive regulation of natural killer cell activation

Across TCGA cell cohorts, RNA activity of the Positive regulation of natural killer cell activation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC2A10, NDUFS6, and CCT5, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of natural killer cell activation activity versus SLC2A10 in BLOOD_Leukemia (Pearson r = -0.93).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SLC2A10 →	-2.363	-1.554	<.001	.002	3	3
OESOPHAGUS	NDUFS6 →	-0.863	-1.541	.002	<.001	3	3
OESOPHAGUS	CCT5 →	-1.232	-1.636	<.001	.002	3	3
UPPER_AERODIGESTIVE_TRACT	NRGN →	+1.085	+1.540	.001	<.001	3	2
UPPER_AERODIGESTIVE_TRACT	PRKCE →	+0.708	+1.360	.008	.001	3	2
UPPER_AERODIGESTIVE_TRACT	NR1D2 →	+0.888	+1.698	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032816 vs SLC2A10 — BLOOD_Leukemia

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