Regulation of natural killer cell activation

Across TCGA patient cohorts, RNA activity of the Regulation of natural killer cell activation pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PIK3CG, ARHGAP9, and CD72, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of natural killer cell activation activity versus PIK3CG in GBM (Pearson r = 0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PIK3CG →	+0.557	+0.380	.003	.001	3	6
GBM	ARHGAP9 →	+0.607	+0.382	.002	<.001	3	6
CCRCC	CD72 →	+0.499	+0.295	.009	.007	2	6
CCRCC	IL12RB1 →	+0.451	+0.316	.006	.004	3	5
COAD	SEPTIN6 →	+0.661	+0.673	.001	.001	3	5
BRCA	FCGR1B →	+0.450	+0.548	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032814 vs PIK3CG — GBM

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