Lacrimal gland development

Across TCGA patient cohorts, RNA activity of the Lacrimal gland development pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are EVL, SOX9, and GRAP2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lacrimal gland development activity versus EVL in OV (Pearson r = -0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	EVL →	-0.434	-0.091	.001	<.001	3	6
LSCC	SOX9 →	+1.027	+0.141	<.001	<.001	3	5
GBM	GRAP2 →	-0.994	-0.141	<.001	<.001	3	5
HNSC	NR3C1_S134 →	-0.558	-0.156	<.001	<.001	3	5
UCEC	FKBP5 →	-0.558	-0.084	<.001	.002	3	5
LSCC	GIMAP8 →	-0.468	-0.142	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032808 vs EVL — OV

Explore this scatter interactively →