Lacrimal gland development

Across TCGA patient cohorts, RNA activity of the Lacrimal gland development pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRAV6, RPS20, and CHRDL1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lacrimal gland development activity versus TRAV6 in OV (Pearson r = -0.72).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	TRAV6 →	-0.384	-0.222	.003	.005	3	4
LUAD	RPS20 →	+0.319	+0.260	.009	.002	3	4
BRCA	CHRDL1 →	-1.274	-0.580	.001	.001	3	4
PDAC	PIK3CG →	-0.310	-0.257	.007	.003	3	3
PDAC	CD6 →	-0.414	-0.231	<.001	.001	3	3
BRCA	PIP4K2A →	-0.374	-0.473	.002	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032808 vs TRAV6 — OV

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