Receptor catabolic process

Across TCGA patient cohorts, RNA activity of the Receptor catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are VCL_S795, RPL5, and TNS2_S120, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Receptor catabolic process activity versus VCL_S795 in CCRCC (Pearson r = 0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	VCL_S795 →	+0.387	+0.050	.007	<.001	3	8
BRCA	RPL5 →	-0.227	-0.047	<.001	<.001	3	8
BRCA	TNS2_S120 →	+0.396	+0.031	.001	.002	3	8
GBM	ISLR →	+0.655	+0.066	<.001	<.001	3	7
OV	RPL4 →	-0.374	-0.056	<.001	<.001	3	7
CCRCC	GSN →	+0.416	+0.039	.004	.003	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032801 vs VCL_S795 — CCRCC

Explore this scatter interactively →