Receptor catabolic process

Across TCGA patient cohorts, RNA activity of the Receptor catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BRPF1, POLE, and PANK1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Receptor catabolic process activity versus BRPF1 in LUAD (Pearson r = -0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	BRPF1 →	-0.230	-0.290	.007	.006	3	5
LUAD	POLE →	-0.522	-0.305	<.001	<.001	3	5
OV	PANK1 →	-0.684	-0.181	.001	.002	3	5
OV	COPZ2 →	+0.981	+0.191	<.001	<.001	3	5
OV	RPLP0 →	-0.938	-0.289	<.001	.003	3	5
UCEC	DDX55 →	-0.562	-0.859	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032801 vs BRPF1 — LUAD

Explore this scatter interactively →