Receptor catabolic process

Across TCGA cell cohorts, RNA activity of the Receptor catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DNMT1, UBA1, and AP1G2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Receptor catabolic process activity versus DNMT1 in SKIN (Pearson r = 0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	DNMT1 →	+0.555	+0.749	.003	.001	3	4
LIVER	UBA1 →	+0.521	+0.396	.009	.002	3	4
LIVER	AP1G2 →	-0.864	-0.377	.006	.004	3	4
OVARY	AGO1 →	+0.467	+0.405	.008	.009	3	4
PANCREAS	RTP4 →	-1.732	-0.905	.003	.006	3	4
PANCREAS	EIF2B3 →	+0.832	+0.588	.001	.009	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032801 vs DNMT1 — SKIN

Explore this scatter interactively →