Negative regulation of CREB transcription factor activity

pathway activity — cross-omics
GO:0032792Cross-omicsPROTEIN-MS → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Negative regulation of CREB transcription factor activity pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are USP16_S552, DENND5A_S836, and STXBP5_S692, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LSCCUSP16_S552 →+0.523+0.871<.001<.00124
OVDENND5A_S836 →-1.029-1.094<.001<.00133
CCRCCSTXBP5_S692 →+0.829+1.600<.001<.00133
LSCCSCAF11_S832 →-1.766-0.932.003.00533
GBMMARCHF7_S691 →+0.962+0.197<.001<.00133
OVSPAST_S245 →-1.007-0.572<.001.00532
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration