Ribosome disassembly

Across TCGA patient cohorts, RNA activity of the Ribosome disassembly pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GOLGA1, ANAPC2, and SETX, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ribosome disassembly activity versus GOLGA1 in OV (Pearson r = 0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	GOLGA1 →	+0.276	+0.035	<.001	<.001	3	6
LSCC	ANAPC2 →	+0.149	+0.042	.001	.003	3	5
PDAC	SETX →	+0.198	+0.041	.006	.001	3	5
PDAC	FUBP3 →	+0.169	+0.052	<.001	<.001	3	5
LSCC	IARS1 →	+0.164	+0.042	<.001	<.001	3	5
PDAC	KANSL3_S736 →	+0.730	+0.053	.005	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032790 vs GOLGA1 — OV

Explore this scatter interactively →