Ribosome disassembly

Across TCGA patient cohorts, RNA activity of the Ribosome disassembly pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MIR125B1, NRXN2, and FLNC, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ribosome disassembly activity versus MIR125B1 in OV (Pearson r = -0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	MIR125B1 →	-1.482	-0.235	<.001	<.001	3	5
OV	NRXN2 →	-0.624	-0.249	.002	<.001	3	4
OV	FLNC →	-1.347	-0.284	<.001	<.001	3	4
OV	ADAM8 →	-0.819	-0.238	.003	<.001	3	4
OV	SLC45A1 →	-0.734	-0.260	<.001	<.001	3	4
UCEC	KCNJ2 →	-0.474	-0.158	.008	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032790 vs MIR125B1 — OV

Explore this scatter interactively →