Ribosome disassembly

Across TCGA cell cohorts, RNA activity of the Ribosome disassembly pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FICD, KITLG, and ZNF490, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FICD grouped by Ribosome disassembly-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	FICD →	-0.557	-0.170	.009	.002	3	5
URINARY_TRACT	KITLG →	+1.463	+0.192	.005	.009	2	5
LUNG_NSCLC_LUSC	ZNF490 →	-0.511	-0.187	.002	<.001	3	4
PANCREAS	UCK1 →	-0.625	-0.194	.001	.008	3	4
BLOOD_Myeloma	CIR1 →	-0.854	-0.427	.003	.002	3	4
BLOOD_Lymphoma	RAB23 →	+1.172	+0.315	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FICD by Ribosome disassembly activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →