Ribosome disassembly

Across TCGA cell cohorts, RNA activity of the Ribosome disassembly pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UFL1, ATG5, and UFSP2, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ribosome disassembly activity versus UFL1 in BREAST (Pearson r = 0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	UFL1 →	+0.776	+0.068	<.001	<.001	3	14
BREAST	ATG5 →	+1.037	+0.076	<.001	.001	3	13
PANCREAS	UFSP2 →	+0.645	+0.067	<.001	<.001	3	13
BREAST	CDC40 →	+0.915	+0.088	<.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	MAP3K7 →	+0.714	+0.082	.001	<.001	3	12
BLOOD_Lymphoma	COPB2 →	+1.103	+0.081	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032790 vs UFL1 — BREAST

Explore this scatter interactively →