Ribosome disassembly

Across TCGA cell cohorts, RNA activity of the Ribosome disassembly pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GTF2H3, TUT1, and RBM19, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ribosome disassembly activity versus GTF2H3 in CNS (Pearson r = 0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	GTF2H3 →	+0.505	+0.190	.001	.004	2	6
CNS	TUT1 →	+0.515	+0.176	.007	<.001	3	5
PANCREAS	RBM19 →	+0.745	+0.201	.001	.006	3	5
BREAST	PHB →	+0.707	+0.139	.006	.005	3	5
BLOOD_Myeloma	MTERF4 →	+0.756	+0.210	.004	.009	3	5
PANCREAS	MRPL10 →	+0.647	+0.206	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032790 vs GTF2H3 — CNS

Explore this scatter interactively →