"Positive regulation of DNA-templated transcription, elongation"

Across TCGA patient cohorts, RNA activity of the "Positive regulation of DNA-templated transcription, elongation" pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPL5, SEPTIN4_S432, and C1QA, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Positive regulation of DNA-templated transcription, elongation" activity versus RPL5 in OV (Pearson r = -0.45).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	RPL5 →	-0.200	-0.050	.001	<.001	3	6
PDAC	SEPTIN4_S432 →	+0.547	+0.033	.001	<.001	3	6
CCRCC	C1QA →	+0.537	+0.031	.003	.001	3	5
CCRCC	ITIH1 →	+0.617	+0.039	<.001	<.001	3	5
CCRCC	MFAP5 →	+0.576	+0.026	.001	.002	3	5
PDAC	PALM_S116 →	+0.658	+0.032	.008	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032786 vs RPL5 — OV

Explore this scatter interactively →