"Positive regulation of DNA-templated transcription, elongation"

Across TCGA cell cohorts, RNA activity of the "Positive regulation of DNA-templated transcription, elongation" pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CPED1, MAP3K7, and F12, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CPED1 grouped by "Positive regulation of DNA-templated transcription, elongation"-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	CPED1 →	-2.154	-0.281	<.001	<.001	3	4
URINARY_TRACT	MAP3K7 →	-0.876	-0.294	.002	<.001	3	4
OESOPHAGUS	F12 →	+1.766	+0.177	<.001	<.001	3	4
PANCREAS	ARL3 →	-0.714	-0.187	.002	.001	3	4
CNS	SNTA1 →	-0.871	-0.134	.001	.005	3	4
STOMACH	NLGN2 →	-2.795	-0.387	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CPED1 by "Positive regulation of DNA-templated transcription, elongation" activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →