"Positive regulation of DNA-templated transcription, elongation"

Across TCGA cell cohorts, RNA activity of the "Positive regulation of DNA-templated transcription, elongation" pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SUMF1, E2F3, and PRPF4B, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Positive regulation of DNA-templated transcription, elongation" activity versus SUMF1 in STOMACH (Pearson r = -0.65).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	SUMF1 →	-1.278	-1.254	<.001	<.001	3	5
BONE	E2F3 →	+1.105	+1.147	.001	.001	3	5
BONE	PRPF4B →	+1.045	+1.350	.004	<.001	3	5
BREAST	NASP →	+0.860	+0.986	.003	<.001	3	5
BREAST	NUP54 →	+0.419	+0.638	.006	.001	3	5
BONE	DHX33 →	+0.899	+0.935	.007	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032786 vs SUMF1 — STOMACH

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