"Negative regulation of DNA-templated transcription, elongation"

Across TCGA patient cohorts, RNA activity of the "Negative regulation of DNA-templated transcription, elongation" pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RSRC1, MCM2_S41, and MSH6, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Negative regulation of DNA-templated transcription, elongation" activity versus RSRC1 in HNSC (Pearson r = 0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RSRC1 →	+0.381	+0.097	<.001	.001	3	6
BRCA	MCM2_S41 →	+0.576	+0.036	.001	<.001	3	6
HNSC	MSH6 →	+0.508	+0.082	.002	.001	3	6
COAD	CTNNBL1 →	+0.234	+0.034	<.001	<.001	3	6
LSCC	FUS →	+0.433	+0.049	<.001	<.001	3	6
LSCC	ORC3 →	+0.354	+0.052	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032785 vs RSRC1 — HNSC

Explore this scatter interactively →