"Negative regulation of DNA-templated transcription, elongation"

Across TCGA patient cohorts, RNA activity of the "Negative regulation of DNA-templated transcription, elongation" pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CENPH, FOXM1, and RFC5, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Negative regulation of DNA-templated transcription, elongation" activity versus CENPH in LSCC (Pearson r = 0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CENPH →	+0.952	+0.341	<.001	<.001	3	7
BRCA	FOXM1 →	+0.860	+0.190	.007	.001	3	6
LSCC	RFC5 →	+0.870	+0.312	<.001	<.001	3	6
GBM	CDCA3 →	+0.586	+0.246	.002	<.001	3	6
GBM	HELLS →	+0.876	+0.221	<.001	<.001	3	6
OV	MSRB3 →	-0.955	-0.178	.001	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032785 vs CENPH — LSCC

Explore this scatter interactively →