"Negative regulation of DNA-templated transcription, elongation"

Across TCGA patient cohorts, RNA activity of the "Negative regulation of DNA-templated transcription, elongation" pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SRSF11, FEN1, and REXO4_S111, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Negative regulation of DNA-templated transcription, elongation" activity versus SRSF11 in GBM (Pearson r = 0.46).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SRSF11 →	+0.239	+0.226	<.001	<.001	3	7
GBM	FEN1 →	+0.464	+0.199	<.001	<.001	3	7
OV	REXO4_S111 →	+1.012	+0.221	.001	<.001	3	6
LSCC	ACTL6A_S233 →	+0.824	+0.259	<.001	<.001	3	6
GBM	RFC5 →	+0.468	+0.244	<.001	<.001	3	6
GBM	SF3B6 →	+0.343	+0.251	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032785 vs SRSF11 — GBM

Explore this scatter interactively →