"Negative regulation of DNA-templated transcription, elongation"

Across TCGA cell cohorts, RNA activity of the "Negative regulation of DNA-templated transcription, elongation" pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZBTB42, TTK, and CDKN1A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZBTB42 grouped by "Negative regulation of DNA-templated transcription, elongation"-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	ZBTB42 →	+0.939	+0.291	.003	<.001	3	5
LUNG_NSCLC_LUSC	TTK →	-1.113	-0.144	.002	.003	3	5
KIDNEY	CDKN1A →	+2.297	+0.235	.009	.003	3	5
KIDNEY	RIT1 →	+1.375	+0.276	<.001	<.001	3	5
KIDNEY	PLK1 →	-1.114	-0.214	.005	.006	3	4
BONE	FH →	-1.802	-0.311	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZBTB42 by "Negative regulation of DNA-templated transcription, elongation" activity — BONE

Explore this box plot interactively →