"Negative regulation of DNA-templated transcription, elongation"

Across TCGA cell cohorts, RNA activity of the "Negative regulation of DNA-templated transcription, elongation" pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRR3, MEX3A, and LUC7L2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Negative regulation of DNA-templated transcription, elongation" activity versus PRR3 in PANCREAS (Pearson r = 0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	PRR3 →	+0.844	+0.176	<.001	<.001	3	6
OVARY	MEX3A →	+2.066	+0.273	.004	.004	3	6
URINARY_TRACT	LUC7L2 →	+0.675	+0.448	.002	<.001	3	6
BREAST	NASP →	+1.029	+0.208	<.001	<.001	3	6
BLOOD_Leukemia	FAM171A2 →	+1.053	+0.209	.003	.006	3	6
BLOOD_Leukemia	TBC1D16 →	+1.602	+0.213	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032785 vs PRR3 — PANCREAS

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