Regulation of DNA-templated transcription elongation

Across TCGA patient cohorts, RNA activity of the Regulation of DNA-templated transcription elongation pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPL5, VCAN, and CA12, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of DNA-templated transcription elongation activity versus RPL5 in GBM (Pearson r = -0.50).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RPL5 →	-0.251	-0.034	<.001	<.001	3	6
CCRCC	VCAN →	+0.860	+0.026	.003	.001	2	6
LSCC	CA12 →	-0.842	-0.025	.002	.009	3	5
COAD	GSPT1 →	-0.240	-0.034	<.001	<.001	3	5
HNSC	RCOR3 →	+0.343	+0.061	.001	.004	3	5
GBM	RPL30 →	-0.310	-0.044	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032784 vs RPL5 — GBM

Explore this scatter interactively →