Regulation of DNA-templated transcription elongation

Across TCGA patient cohorts, RNA activity of the Regulation of DNA-templated transcription elongation pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CRYAB, ISM1, and MEDAG, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of DNA-templated transcription elongation activity versus CRYAB in COAD (Pearson r = -0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CRYAB →	-0.853	-0.924	.008	.009	3	3
OV	ISM1 →	-1.439	-0.247	<.001	.001	3	2
OV	MEDAG →	-1.823	-0.260	<.001	<.001	3	2
OV	COMP →	-1.790	-0.202	.005	.009	3	2
OV	CXCL12 →	-1.948	-0.270	<.001	<.001	3	2
OV	SEPTIN4 →	-0.641	-0.288	.002	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032784 vs CRYAB — COAD

Explore this scatter interactively →