Regulation of DNA-templated transcription elongation

Across TCGA cell cohorts, RNA activity of the Regulation of DNA-templated transcription elongation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PUM1, ATP8B2, and PRPSAP2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PUM1 grouped by Regulation of DNA-templated transcription elongation-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PUM1 →	-0.591	-0.133	.005	.004	3	4
BLOOD_Leukemia	ATP8B2 →	-1.860	-0.210	.002	<.001	3	4
LUNG_NSCLC_LUAD	PRPSAP2 →	-0.600	-0.108	.003	.004	3	4
LUNG_NSCLC_LUSC	RALY →	-0.774	-0.155	<.001	.004	3	4
PANCREAS	CEMIP →	+2.306	+0.169	.002	<.001	3	4
PANCREAS	F12 →	+1.634	+0.165	<.001	.008	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PUM1 by Regulation of DNA-templated transcription elongation activity — BLOOD_Leukemia

Explore this box plot interactively →