Positive regulation of ATP-dependent activity

Across TCGA patient cohorts, RNA activity of the Positive regulation of ATP-dependent activity pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MCM2_S139, RFC2, and RRM2, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of ATP-dependent activity activity versus MCM2_S139 in BRCA (Pearson r = 0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MCM2_S139 →	+0.863	+0.034	<.001	<.001	3	9
LSCC	RFC2 →	+0.401	+0.051	<.001	<.001	3	8
LUAD	RRM2 →	+0.735	+0.057	<.001	<.001	3	8
LUAD	RRM2_S20 →	+1.243	+0.057	<.001	<.001	3	8
BRCA	CRYL1 →	-0.562	-0.046	<.001	<.001	3	8
UCEC	MCM2 →	+0.668	+0.081	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032781 vs MCM2_S139 — BRCA

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