Positive regulation of ATP-dependent activity

Across TCGA cell cohorts, RNA activity of the Positive regulation of ATP-dependent activity pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PHYKPL, PLEKHJ1, and GUF1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PHYKPL grouped by Positive regulation of ATP-dependent activity-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	PHYKPL →	-1.063	-0.374	<.001	<.001	3	4
BLOOD_Myeloma	PLEKHJ1 →	-0.837	-0.291	.001	<.001	3	3
BLOOD_Myeloma	GUF1 →	-1.018	-0.272	<.001	.002	3	3
BLOOD_Myeloma	CLGN →	-3.426	-0.374	<.001	<.001	3	3
BLOOD_Myeloma	ABHD18 →	-0.915	-0.294	<.001	.001	3	3
BLOOD_Myeloma	BOD1L1 →	-0.812	-0.268	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PHYKPL by Positive regulation of ATP-dependent activity activity — LIVER

Explore this box plot interactively →