Positive regulation of ATP-dependent activity

Across TCGA cell cohorts, RNA activity of the Positive regulation of ATP-dependent activity pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CBX1, ILF3, and DNAJC9, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of ATP-dependent activity activity versus CBX1 in PANCREAS (Pearson r = 0.69).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	CBX1 →	+1.289	+0.327	<.001	.001	3	5
PANCREAS	ILF3 →	+0.865	+0.270	<.001	<.001	3	5
BREAST	DNAJC9 →	+0.768	+0.226	.005	.001	3	5
PANCREAS	MLLT1 →	+0.917	+0.325	<.001	.001	3	5
PANCREAS	RAVER1 →	+0.852	+0.316	.004	<.001	3	5
STOMACH	BRD3OS →	+1.996	+0.231	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032781 vs CBX1 — PANCREAS

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