Negative regulation of ATP-dependent activity

Across TCGA patient cohorts, RNA activity of the Negative regulation of ATP-dependent activity pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RECK, L3HYPDH, and SBSPON, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of ATP-dependent activity activity versus RECK in BRCA (Pearson r = 0.18).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RECK →	+0.431	+0.044	<.001	<.001	3	8
GBM	L3HYPDH →	+0.561	+0.085	.001	<.001	3	8
BRCA	SBSPON →	+0.720	+0.039	<.001	<.001	3	7
HNSC	SGCD →	+0.917	+0.089	<.001	.001	3	7
BRCA	SVIL_S961 →	+1.391	+0.102	<.001	<.001	3	7
UCEC	TNS2 →	+0.454	+0.091	<.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032780 vs RECK — BRCA

Explore this scatter interactively →