Negative regulation of ATP-dependent activity

Across TCGA patient cohorts, RNA activity of the Negative regulation of ATP-dependent activity pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TP53, S100A6, and LINC01006, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of ATP-dependent activity activity versus TP53 in LSCC (Pearson r = 0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TP53 →	+0.682	+0.223	<.001	<.001	3	3
PDAC	S100A6 →	-0.550	-0.237	<.001	<.001	3	3
LUAD	LINC01006 →	+0.466	+0.230	.003	.005	3	3
GBM	ZNF417 →	-0.325	-0.590	.002	.002	3	3
LUAD	E2F2 →	+0.686	+0.338	<.001	.006	3	3
BRCA	ZNF45 →	-0.356	-0.191	.002	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032780 vs TP53 — LSCC

Explore this scatter interactively →