Negative regulation of ATP-dependent activity

Across TCGA cell cohorts, RNA activity of the Negative regulation of ATP-dependent activity pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are POLR1E, THG1L, and SPHK1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of ATP-dependent activity activity versus POLR1E in BREAST (Pearson r = 0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	POLR1E →	+1.418	+0.236	.002	.006	3	4
BREAST	THG1L →	+0.832	+0.273	.004	.002	3	3
LUNG_NSCLC_LUAD	SPHK1 →	+1.421	+0.167	<.001	<.001	3	3
LUNG_NSCLC_LUAD	P4HTM →	-0.814	-0.224	<.001	<.001	3	3
URINARY_TRACT	TANC1 →	-1.225	-0.311	.002	.001	2	4
UPPER_AERODIGESTIVE_TRACT	CARS2 →	+0.780	+0.222	.003	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032780 vs POLR1E — BREAST

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