Negative regulation of monooxygenase activity

pathway activity — cross-omics
GO:0032769Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Negative regulation of monooxygenase activity pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPSAP54, BAG3, and RPL7P26, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
OVRPSAP54 →-2.082-0.218<.001<.00133
OVBAG3 →+0.991+0.176.001.00733
OVRPL7P26 →-1.031-0.126.008.00433
OVDHFRP1 →-0.865-0.230<.001<.00133
OVRPL22P10 →-1.099-0.129<.001.00333
OVRPL7AP34 →-1.026-0.186<.001.00233
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

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