Positive regulation of interleukin-6 production

Across TCGA cell cohorts, RNA activity of the Positive regulation of interleukin-6 production pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC22A18, TMOD1, and ANKIB1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC22A18 grouped by Positive regulation of interleukin-6 production-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	SLC22A18 →	-1.482	-0.243	.005	.009	3	4
CNS	TMOD1 →	-1.439	-0.146	.002	.002	3	4
CNS	ANKIB1 →	-0.626	-0.129	.001	.008	3	4
OVARY	NCSTN →	-0.566	-0.302	.007	<.001	3	3
LUNG_NSCLC_LUSC	PYGB →	-1.109	-0.209	.007	.001	3	3
LUNG_NSCLC_LUSC	EXOSC8 →	+0.889	+0.265	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC22A18 by Positive regulation of interleukin-6 production activity — BLOOD_Lymphoma

Explore this box plot interactively →