Positive regulation of interleukin-6 production

Across TCGA cell cohorts, RNA activity of the Positive regulation of interleukin-6 production pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC15A3, TRIM34, and LRRK1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of interleukin-6 production activity versus SLC15A3 in BLOOD_Lymphoma (Pearson r = -0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	SLC15A3 →	-2.546	-0.195	<.001	<.001	3	6
LARGE_INTESTINE	TRIM34 →	-1.013	-0.145	.006	.007	3	6
BLOOD_Lymphoma	LRRK1 →	-1.877	-0.221	<.001	<.001	3	6
LUNG_SCLC	RUNDC1 →	-0.904	-0.222	<.001	<.001	3	5
OESOPHAGUS	PRKX →	+0.870	+0.132	<.001	.003	3	5
BREAST	PAPOLG →	+0.709	+0.185	.003	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032755 vs SLC15A3 — BLOOD_Lymphoma

Explore this scatter interactively →