Positive regulation of interleukin-5 production

Across TCGA patient cohorts, RNA activity of the Positive regulation of interleukin-5 production pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CAD, FKBP4, and COIL_T303, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of interleukin-5 production activity versus CAD in LSCC (Pearson r = -0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CAD →	-0.264	-0.076	.001	<.001	3	6
LSCC	FKBP4 →	-0.536	-0.104	<.001	<.001	3	5
OV	COIL_T303 →	-0.986	-0.043	<.001	<.001	3	5
LSCC	IL33 →	+0.774	+0.097	<.001	<.001	3	5
LSCC	CACYBP →	-0.323	-0.056	<.001	<.001	3	5
LSCC	RPL22 →	-0.333	-0.077	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032754 vs CAD — LSCC

Explore this scatter interactively →