Positive regulation of interleukin-5 production

Across TCGA patient cohorts, RNA activity of the Positive regulation of interleukin-5 production pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GCNT1P3, IL1RAP, and RN7SKP296, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of interleukin-5 production activity versus GCNT1P3 in GBM (Pearson r = 0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	GCNT1P3 →	+1.481	+0.947	<.001	<.001	3	6
GBM	IL1RAP →	+1.730	+0.814	<.001	<.001	3	5
GBM	RN7SKP296 →	+1.510	+0.824	<.001	<.001	3	5
BRCA	LPIN1 →	-1.016	-0.579	<.001	<.001	3	4
BRCA	TTYH1 →	-0.696	-0.506	<.001	<.001	3	4
LSCC	TREM1 →	+1.145	+0.417	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032754 vs GCNT1P3 — GBM

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