Positive regulation of interleukin-5 production

Across TCGA cell cohorts, RNA activity of the Positive regulation of interleukin-5 production pathway is significantly associated with the shRNA dependency of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are YY1P2, RIOX2, and GPR151, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, YY1P2 grouped by Positive regulation of interleukin-5 production-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	YY1P2 →	+0.334	+0.111	<.001	.005	3	4
BREAST	RIOX2 →	-0.158	-0.125	<.001	<.001	3	4
PANCREAS	GPR151 →	-0.153	-0.076	.006	.001	3	4
LARGE_INTESTINE	OR2T5 →	-0.153	-0.076	<.001	<.001	3	3
BREAST	PHTF1 →	-0.145	-0.133	.001	<.001	3	3
LIVER	TUBB2A →	-0.346	-0.103	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

YY1P2 by Positive regulation of interleukin-5 production activity — STOMACH

Explore this box plot interactively →