Positive regulation of interleukin-5 production

Across TCGA cell cohorts, RNA activity of the Positive regulation of interleukin-5 production pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZBTB32, MPLKIP, and STK35, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of interleukin-5 production activity versus ZBTB32 in BLOOD_Leukemia (Pearson r = 0.85).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ZBTB32 →	+0.466	+1.479	.004	<.001	3	2
BLOOD_Leukemia	MPLKIP →	-0.375	-1.396	.005	<.001	2	3
PANCREAS	STK35 →	-1.315	-1.702	.009	.004	2	2
PANCREAS	ZNF550 →	-0.901	-1.702	.006	.004	2	2
BREAST	PRDM4 →	+1.039	+1.842	<.001	.005	2	2
BREAST	SDC1 →	+1.700	+1.842	.003	.005	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032754 vs ZBTB32 — BLOOD_Leukemia

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