Positive regulation of interleukin-4 production

Across TCGA patient cohorts, RNA activity of the Positive regulation of interleukin-4 production pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IL2RA, SCIMP, and ZC3H12D, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of interleukin-4 production activity versus IL2RA in GBM (Pearson r = 0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	IL2RA →	+1.042	+0.269	.001	.001	3	8
BRCA	SCIMP →	+0.818	+1.215	<.001	<.001	3	8
HNSC	ZC3H12D →	+0.654	+0.334	<.001	<.001	3	8
HNSC	CEACAM4 →	+0.921	+0.320	<.001	<.001	3	8
BRCA	ARHGAP9 →	+1.237	+1.433	<.001	<.001	3	8
GBM	SIGLEC10 →	+1.038	+0.351	.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032753 vs IL2RA — GBM

Explore this scatter interactively →