Positive regulation of interleukin-4 production

Across TCGA cell cohorts, RNA activity of the Positive regulation of interleukin-4 production pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPP2R3A, PINK1, and TAF10, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PPP2R3A grouped by Positive regulation of interleukin-4 production-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	PPP2R3A →	-0.623	-0.727	.008	.003	3	4
SKIN	PINK1 →	-0.615	-0.830	.009	.002	3	4
LUNG_NSCLC_LUSC	TAF10 →	-0.788	-1.033	.007	.001	3	3
KIDNEY	MYADM →	+1.862	+0.882	.005	.004	3	3
KIDNEY	PTPRU →	+1.578	+0.811	.004	.009	3	3
LUNG_SCLC	DNAJC17 →	+0.846	+0.918	.004	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PPP2R3A by Positive regulation of interleukin-4 production activity — CNS

Explore this box plot interactively →