Positive regulation of interleukin-4 production

Across TCGA cell cohorts, RNA activity of the Positive regulation of interleukin-4 production pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC7A5, ARHGDIA, and IER3, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of interleukin-4 production activity versus SLC7A5 in LUNG_NSCLC_LUAD (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SLC7A5 →	+1.404	+0.815	.001	.002	3	7
SOFT_TISSUE	ARHGDIA →	-0.958	-1.529	<.001	<.001	3	4
BLOOD_Lymphoma	IER3 →	+3.166	+0.328	.002	.008	3	4
BLOOD_Lymphoma	SOCS3 →	+5.229	+0.675	<.001	.004	3	4
BLOOD_Lymphoma	ZNF468 →	-1.517	-0.535	.002	.005	3	4
OVARY	RNASEH2C →	-0.858	-0.976	.003	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032753 vs SLC7A5 — LUNG_NSCLC_LUAD

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