Positive regulation of interleukin-4 production

Across TCGA cell cohorts, RNA activity of the Positive regulation of interleukin-4 production pathway is significantly associated with the protein abundance of multiple proteins, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SLC7A5, SLC3A2, and CEBPB, each associated with the pathway in up to 18 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of interleukin-4 production activity versus SLC7A5 in STOMACH (Pearson r = 0.74).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	SLC7A5 →	+2.658	+1.469	<.001	<.001	3	18
LUNG_SCLC	SLC3A2 →	+1.854	+1.298	<.001	<.001	3	16
BONE	CEBPB →	+2.155	+0.997	<.001	.005	3	11
LIVER	GLOD4 →	-1.930	-1.199	.005	.003	3	9
URINARY_TRACT	GMFB →	-2.441	-1.395	.001	.003	2	8
STOMACH	EBNA1BP2 →	+0.636	+0.988	.004	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032753 vs SLC7A5 — STOMACH

Explore this scatter interactively →